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| Getting There Faster wtih MDL® Discovery Predictive Science |
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Absorption,
distribution, metabolism, excretion, and toxicity (ADMET) are critical
properties studied in drug discovery and design. More than 60% of all
compounds fail in development and clinical trials because of adverse
ADMET characteristics. Fortunately, with higher throughput assays, more
observed data, and better predictive models, researchers can now assess
ADMET properties earlier in the discovery process, potentially reaping
substantial savings in research time and costs. (Molecular Connection Vol 20 No 2, Summer 2002, pp 12-14) |
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| ACD: A Key Component of University Lab's Successful Drug Design Strategy |
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This study
illustrates the use of MDL® Available Chemicals Directory (ACD) and DOCK
for rational drug design at Jefferson Medical College's Peptide
Chemistry Laboratory. (Molecular Connection Vol. 19 No. 1, Spring 2000, pp 10-11) |
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| Aventis Builds a Global Registration System |
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The Aventis team
established a guiding principle early in the project: The new system
should conform to the scientific workflow, not the confines of software
or technology. The result was consistent, high-quality data at sites
worldwide, and integrated access to a global network of information. (Molecular Connection Vol 20 No 2, Summer 2002, pp 8-9) |
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| MDL Databases Assist with Identifying Drug-Like Compounds |
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This study
describes how Jing Wang and Kal Ramnarayan of Structural Bioinformatics,
Inc. (San Diego, CA) developed a computational method for determining
which compounds are most like drugs. (Molecular Connection Vol. 19 No. 1, Spring 2000, pp 16-17) |
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| Applying combinatorial chemistry to lead optimization |
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Working with focused libraries: Using MDL Software and Argonaut Instrumentation (Molecular Connection Vol. 19 No. 2, Winter 2000, pp 6-9) |
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| Data cartridges |
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Planning a
successful migration: moving molecule databases to data cartridge format
in MDL Relational Chemistry Server (formerly ISIS/Direct) (Molecular Connection Vol. 19 No. 2, Winter 2000, pp 14-17) |
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| Reaction Management |
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BASF Introduces an ISIS-based Reaction Management System. (Molecular Connection Vol. 18 No. 4, Fall 1999, pp 10-11, 23) |
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| At the Bench with MDL Report Manager |
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See how easy it is
to create ad hoc and regularly scheduled multi-sectioned reports,
including structures and data from Oracle and MDL databases. (Molecular Connection Vol. 20 No. 1, Spring 2002, pp 10-11) |
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| Chemscape Manages Firmenich's R&D Data |
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Development of a multi-site intranet application for handling structures, reactions, and spectral data. (Molecular Connection Vol. 19 No. 2, Winter 2000, pp 12-13) |
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| Using MDL Metabolite to probe the probable |
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Prioritizing new syntheses with Metabolite by assessing likely metabolic fate. (Molecular Connection Vol. 19 No. 1, Spring 2000, pp 12-13) |
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| Assay Explorer Developers’ Network reaches out |
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Web site expands to offer tips and tools to researchers and administrators. (Molecular Connection Vol. 20 No. 3, Fall 2002, pp 10-11) |
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| LitLink's Interlinking Community |
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LitLink/Pro Server
is more than just the first commercial system to offer dynamic linking
to the primary literature—it's the only system that supports multiple
applications, document sources, and document types. (Molecular Connection Vol. 19 No. 1, Spring 2000, pp 8-9,19) |
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| A boon to scientists and developers |
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The next-generation in chemical drawing has arrived, giving scientists and developers cause to celebrate. (Molecular Connection Vol. 20 No. 3, Fall 2002, p 16) |
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| MDL and Elsevier Science Work Together to Link Scientists' Desktops to the Chemical Literature |
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ONE-CLICK access to the full text of journal citations is now available in IDdb3 via MDL's LitLink
service. LitLink is an add-on feature, which can be purchased from MDL, and allows your company
to set up a local server that holds details of your preferences for getting full-text journal articles. (Molecular Connection Vol. 17 No. 4, Fall 1998, pp 24-25) |
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| LitLink/Pro Server |
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LitLink/Pro Server: Simple to use, configure, and customize (Molecular Connection Vol. 19 No. 1, Spring 2000, pp 8-9, 19) |
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| LitLink Delivers Articles at the Click of a Button |
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ONE-CLICK access to
the full text of journal citations is now available in IDdb3 via MDL's
LitLink service. LitLink is an add-on feature, which can be purchased
from MDL, and allows your company to set up a local server that holds
details of your preferences for getting full-text journal articles. |
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| MDL® Discovery Predictive Science Workflow Solutions |
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Could any of these
compounds have adverse effects? Identify promising compounds early with
MDL Discovery Predictive Science solutions. |
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| MDL® Discovery Chemistry Workflow Solutions |
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Spending too much
time planning, tracking, and analyzing your syntheses? Simplify your
workflow with MDL Discovery Chemistry workflow solutions. |
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| MDL® Discovery Biology Workflow Solutions |
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Which "active" in your assay is the best lead candidate? Support your decision with MDL Discovery Biology workflow solutions. |
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